The study on canine pyometra was conducted to assess the alteration in clinico-haemato-biochemical status before and after

ovariohysterectomy. Signalment and history recording of six bitches was followed by clinical examination, ultrasonography and blood sampling. Most common clinical signs were vulvar discharge, inappetance, polydipsia, polyuria, vomition and paresis. At presentation, uterine diameters ranged from 1.3 to 5.0 cm along with leukocytosis, neutrophilia and lymphopenia. Levels of BUN, creatinine, and ALP were elevated. Five out of six bitches had plasma P4 concentration above basal (> 1.0 ng/ml) level. The mean haemato-biochemical parameters returned to normal by day ten post-surgery. The progesterone concentration decreased to basal by 10th day. The changes in haemato-biochemical profi le were related to the degree of improvement of the clinical conditions of the bitches. Out of the six bitches, one bitch died on 21st post-operative day while another recovered gradually after initial episodes of severe vomition for a week post-operation.